Principal Investigator/Research Scientist - Brain Trauma Neuroprotection

Full Time
Silver Spring, MD
Up to $119,000 a year
Posted
Job description

Overview

About The Geneva Foundation

The Geneva Foundation is a 501(c)3 nonprofit established in 1993 with the purpose to ensure optimal health for service members and the communities they serve. This purpose is accomplished through our mission to advance military medicine through research, development, and education. Our culture is living our core values that focus on a higher purpose. Geneva serves a diverse population and is committed to making diversity, equity, inclusion and belonging a central focus of the employee experience. As a leader in military medical research, we develop critical lifesaving solutions for the global community – and build rewarding careers for our employees.

Benefits

Our benefits package includes financial rewards that are a significant part of the employee's total rewards compensation package. Geneva's highly competitive benefits include medical, dental, and vision healthcare, Flexible Spending Account, Health Savings account, with employer contribution. Coverage is provided for employees and family members including domestic partners. Short-and long-term disability, Employee Assistance Program, Life & ADD insurance, 403b retirement plan with generous employer match, flexible leave options, 11 paid holidays per year, and up to 4 weeks of paid time off in a rolling year. Employees may qualify for PSLF as Geneva is a 501(c)(3) nonprofit organization. Full time positions come with all benefits. Part time and intermittent positions may vary.

About The Position

The Principal Investigator/Brain Trauma Research Scientist provides scientific expertise in the Brain Trauma Neuroprotection (BTN) branch to develop and transition knowledge and materiel solutions to improve survival and recovery from combat related neurologic injury, including mild, moderate, and severe traumatic brain injury (TBI) from various injury mechanisms across the spectrum of point-of-injury care, acute neurocritical care, long term recovery, chronic neurodegenerative sequela (e.g., CTE/Parkinson's), and spinal cord injury. Small and large animal models of injury include, Penetrating Ballistic-like Brain Injury (PBBI), Projectile Concussive Impact (PCI), fluid percussion brain injury, controlled cortical impact, and polytrauma, such as but not limited to hemorrhage, lung injury, soft tissue injury, bone injury. The BTN conducts all aspects of scientific research experiments according to individual reviewed protocols, communicate and correspond with lead investigator(s) regarding experimental procedures, study progress, concerns about the study, and changes in procedure on a regular and ongoing basis.

Responsibilities

Management Responsibilities:

  • With broad guidance from branch and/or Center leadership (i.e., with the level of independence that would be expected of an associate research professor at an academic institution), lead a multidisciplinary team of doctoral level scientific researchers, to include physicians, psychologists, physiologists, and statisticians
  • Train, mentor, and lead contractor research technicians under the task order

Responsibilities:

  • Ensure documents and management processes comply with all regulatory requirements, both Federal and DoD
  • Participate in the planning of preclinical research experiments accounting for the impact of hemorrhagic shock and traumatic brain injury
  • Determine what pathological characteristics are measurable in the acute, subacute, and chronic periods following brain injury
  • Support and execute protocols focusing on traumatic brain injury (TBI), polytrauma, neuroprotection, non-convulsive seizures, neurorestoration, mitochondrial dysfunction, immune-inflammation, and neurotherapeutic resuscitation; including cumulative effects of "repeated" traumas in these areas
  • Conduct surgical procedures in small and large animals, analyze data related to brain trauma neuroprotection, neurorestoration, and neurotherapeutic research, including therapeutic strategies, blood-brain barrier (BBB) permeability, immune-inflammatory responses, biomarkers, pathology, and sequelae following trauma as well as the molecular and cellular mechanisms of brain injury
  • Perform research tests on the behavioral, physiological, neurophysiological, electrophysiological (including seizures and sleep) and cellular/molecular pathology of neurotrauma, including, but not limited to, Morris water maze, rotarod, novel object recognition, elevated plus maze, monitoring weight, temperature, Neuroscore, righting reflex, EEG recording of seizure and sleep, positron emission tomography analysis, Ultrasonic Vocalization, perfusion, resuscitation, proteomics, necropsy and sample collection procedures, mRNA, miRNA, micro array protein analysis, quantitative PCR, Western blot, or ELISA
  • Critically analyze and review multidisciplinary research proposals and publications for military relevance and scientific adequacy
  • Provide support to monitoring research animals, conducting surgical procedures, and executing the entire research experiments to meet the goals of the tasks, process research data files, and analyze research data; this may include early or late, overnight and/ or weekend shifts
  • Plan and execute research experiments related to polytrauma injury, accounting for the impact of hemorrhagic shock on the progression brain injury using resuscitation approaches that optimize cerebral perfusion and brain salvage, immune- inflammatory responses, other related physiological changes, profiles of pro-inflammatory, apoptotic, and neurotrophic factors, as well as specialized histopathology and immunohistochemistry analysis
  • Examine therapeutic approaches by isobolic design and analysis framework using well-established and promising novel neuro-protective agents, stem-cell based therapies, and novel drug delivery systems
  • Plan and execute research experiments focusing on mitochondrial therapeutic interventions, including allogeneic mitochondrial transplantation, pharmacological approaches, and enhancing mitochondrial bioenergetics
  • Work closely with other Government and Contractor personnel to plan, develop, and gain approval of animal use protocols as required for the performance of this requirement
  • Assist with the preparation of periodic progress reports to funding organizations or agencies as required
  • Collaborate in support of other tasks and projects as appropriate
  • Comply with occupational health and safety standards and other applicable regulations and guidelines, which may include medical surveillance
  • Promote safety and confidentiality of research participants at all times when working with human research studies
  • Promote humane and ethical treatment of animal subjects when working with animal research studies
  • Adhere to Occupational Safety and Health Administration (OSHA), Good Laboratory Practices (GLP) and Good Clinical Practices (GCP)
  • Maintain a collaborative research environment with all site personnel, research participants, The Geneva Foundation, and the prime partner organization

Qualifications

  • Doctorate degree in Psychology or other Behavioral Health fields required
  • 3+ years of experience in the field or in a related area
  • 3+ years knowledge and experience with Department of Defense contracts administration and management, preferred
  • 3+ years medical research project management experience strongly desired, preferably with Department of Defense
  • Proficient in survey development, focus group and interview development, protocol writing, regulatory approval, and quantitative or qualitative analysis
  • Demonstrates expertise in a variety of the field’s concepts, practices, and procedures
  • Relies on extensive experience and judgment to plan and accomplish goals
  • Has knowledge of commonly-used concepts, practices, and procedures within a particular field
  • Must be proficient in statistical analyses
  • Relies on instructions and pre-established guidelines to perform the functions of the job
  • Works under immediate supervision
  • Education and training commensurate with research protocol being conducted
  • Experience with advanced medical technologies preferred
  • Demonstrate competence in oral and written communication
  • Must be organized, attentive to detail, and possess a positive, friendly, and professional demeanor
  • Ability to be flexible with changing priorities and available to interact with employees, clients, and sponsors at all levels
  • Ability to exercise independent judgment in fast-paced, high-pressured environment with strict deadlines and to manage multiple projects
  • Ability to develop strong trusting relationships to gain support and achieve results
  • Computer skills, including at least intermediate experience with Excel and other Microsoft Office software

Job Type: Full-time

Pay: Up to $119,000.00 per year

Benefits:

  • 401(k)
  • Dental insurance
  • Flexible schedule
  • Health insurance
  • Paid time off
  • Vision insurance

Schedule:

  • 8 hour shift
  • Weekend availability

Ability to commute/relocate:

  • Silver Spring, MD: Reliably commute or planning to relocate before starting work (Required)

Education:

  • Doctorate (Required)

Experience:

  • Clinical trials / research: 5 years (Preferred)

Work Location: In person

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